In this paper, we propose a new computational model to predict the mechanical behavior of an electrospun fibrous mat by considering its microstructure and the percentage of the cross-points that are bonded. The lack of knowledge for predicting the mechanical behavior of electrospun fibrous mats may prevent applications utilizing the se mats from reaching their full potential. The micro or nanoscale architectures of these structures significantly affects the mechanical properties of the material. The proposed model can be further considered for clinical applications or may be used for tissue engineering applications.Įlectrospun fibrous mats, characterized by their large surface-to-volume ratios, have unique and beneficial properties for various applications. An extensive finite element analysis was performed in order to optimize the final product. A cavity mold was designed and manufactured and the proposed polymeric valve was then fabricated. Also, we obtained a close match of the stress–strain curves for the aorta in the circumferential and axial directions and anisotropic 10% PVA with 75% initial strain after cycle 3. The tensile properties of the synthesized PVA-BC that were measured are close to those of the human aortic valve leaflet tissue in the two principle directions, radial and circumferential. The biomaterial used for the root was only 10% PVA. The biomaterial used for the aortic valve was a biocompatible hydrogel made of polyvinyl alcohol (PVA) reinforced by bacterial cellulose (BC) natural nanofibers in a combination of 15% PVA and 0.5% BC, by weight fraction. The three-dimensional geometry was developed using two-dimensional images obtained by the radial dissection of an adult human aortic root. To design the geometry of the root, an advanced surfacing technique based on the de Casteljau method (for developing Bezier surfaces) was applied. In this study, a polymeric human aortic root made of hydrogel-based biomaterials is proposed.
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